Transfer of Vascular Endothelial Growth Factor in a Rat Model of Hindlimb Ischemia Endothelium-Dependent Relaxation of Collateral Microvessels After Intramuscular Gene
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چکیده
Satoshi Takeshita, Takaaki Isshiki, Masahiko Ochiai, Koji Eto, Hidezo Mori, Etsuro Tanaka, Transfer of Vascular Endothelial Growth Factor in a Rat Model of Hindlimb Ischemia Endothelium-Dependent Relaxation of Collateral Microvessels After Intramuscular Gene Print ISSN: 0009-7322. Online ISSN: 1524-4539 Copyright © 1998 American Heart Association, Inc. All rights reserved. is published by the American Heart Association, 7272 Greenville Avenue, Dallas, TX 75231 Circulation doi: 10.1161/01.CIR.98.13.1261 1998;98:1261-1263 Circulation. http://circ.ahajournals.org/content/98/13/1261 World Wide Web at: The online version of this article, along with updated information and services, is located on the
منابع مشابه
Endothelium-dependent relaxation of collateral microvessels after intramuscular gene transfer of vascular endothelial growth factor in a rat model of hindlimb ischemia.
BACKGROUND Recent investigations have demonstrated the ability of vascular endothelial growth factor (VEGF) to augment the development of collateral arteries in vivo. In vitro studies have suggested that the use of VEGF also improves the endothelium-dependent relaxation of collaterals at the microvascular level. The purpose of this study was to determine in vivo the extent to which vasomotor re...
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BACKGROUND The purpose of the current study was to examine the contribution of endogenous vascular endothelial growth factor (VEGF) to ischemia-induced angiogenesis and perfusion. METHODS AND RESULTS C57BL/6J mice (n=28) were subjected to unilateral hindlimb ischemia after intravenous injection of recombinant adenoviruses (10(9) plaque-forming units) encoding the ligand-binding ectodomain of ...
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OBJECTIVE Endothelium-derived NO has been shown to mediate the mitogenic effect of vascular endothelial growth factor on cultured microvascular endothelium. To evaluate the role of endothelial NO synthase (eNOS) in angiogenesis in the ischemic hindlimb, we engineered an adenovirus containing human eNOS cDNA. METHODS AND RESULTS After gene transfer, expression of eNOS in cultured cells was det...
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تاریخ انتشار 1998